Founding Director , Innovation Center for Biomedical Informatics, Georgetown University Medical Center
Dr. Madhavan is the Founding Director of the Innovation Center for Biomedical Informatics (ICBI) at the Georgetown University Medical Center and Associate Professor of Oncology. She is a world-class leader in data science, clinical informatics and health IT who is responsible for several biomedical informatics efforts including the Georgetown Database of Cancer (G-DOC) a resource for both researchers and clinicians to realize the goals of personalized medicine, the NCI In Silico Research Center for Excellence, and co-directs Lombardi Cancer Center’s Biostatistics and Bioinformatics shared resource.
She leads the Biomedical Informatics program of the Georgetown-Howard Universities CTSA. In this role, she has enabled access to over 2.5 million patient records from 10 MedStar Health hospitals to translational researchers. She was the PI on the Breast and Colon Cancer Family Registries data center that coordinates public health and epidemiology data across 12 sites in the US, Australia, and Canada. More recently, she has partnered with the FDA on the Center for Excellence in Regulatory Science program to develop evidence bases for pharmacogenomics and vaccine safety. Her group was recently awarded the Massive Data Initiative grant by Georgetown’s McCourt’s School of Public Policy to explore legal and economic barriers to implementing personalized medicine. She has contributed to novel information sciences findings in research articles published in journals such as Nature, Bioinformatics, Molecular and Cell Biology (MCB), AJPM, Frontiers in Oncology, Bioinformatics, Cancer Informatics, and Molecular Cancer Research (MCR).
As Chief Bioinformatics Officer at Perthera Inc., a startup firm in cancer diagnostics, she advises the CEO and CMO on the go-to-market strategy for their primary product, an oncology expert system that uses multi-omic molecular diagnostics and cutting edge Bioinformatics to rank and inform therapeutic options for patients with advanced, refractory cancers.
Prior to joining Georgetown and Perthera, Dr. Madhavan served as the Associate Director of Product and Program Management in the Life sciences informatics area at NCI’s Center for Biomedical Informatics and Information technology. Her work at NCI involved bridging the gap between bench and bedside by enabling researchers and physician scientists to use cutting edge biomedical informatics solutions to identify better therapies for cancer. At NCI she led a group of scientists, physicians and software engineers in building REMBRANDT (REpository for MolecularBRAin Neoplasia DaTa) – a database that hosts and interconnects clinical data points with various genomics datasets from large brain tumor clinical trials. This effort won the prestigious Service to America Award. While at NCI she also established the data coordination center for The Cancer Genome Atlas (TCGA), which managed and analyzed high dimensional genomic data of approximately 100 TB over a period of 3 years.
Dr. Madhavan has a Master of Science in Information Technology from University of Maryland and a Ph.D. in Molecular Biology and Biological Sciences from the Uniformed Services University for the Health Sciences through a highly ranked Indo-US Collaborative program.